No specific dose adjustment advised when tofacitinib coadministered with powerful CYP2C19 inhibitors; lower tofacitinib dose if coadministered with both equally moderate CYP3A4 and powerful CYP2C19 inhibitors .Hepatic impairment: In clients with critical hepatic impairment, modafinil dose must be diminished by just one-50 percent of the standard d

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